What is therapeutic interchange and how is it used in formulary management?

• A. Therapeutic interchange is the practice of prescribing the newest drug available in all cases.
• B. Therapeutic interchange focuses solely on cost without regard to safety or efficacy.
• C. Therapeutic interchange involves switching to OTC alternatives.
• D. Therapeutic interchange replaces a prescribed drug with a therapeutically equivalent, clinically appropriate alternative to improve safety or reduce cost, within formulary guidelines.

Answer: (D)